We demonstrate that combining the unique properties of superhydrophilicity and superhydrophobicity on the same surface in micropatterns generates unexpected and interesting applications. We use the micropatterns for digital liquid patterning – a simple, maskless method to generate complex water droplets – to create patterns of particles, cells, hydrogels, and complex liquid gradients. We also use the micropatterns to create arrays of thousands of isolated droplets in one simple step. We can confine cells in each individual microdroplet or hydrogel to screening, for example, single cells, non-adherent cells, and cells in 3D microenvironments. We can print different chemicals or bioactive molecules in each superhydrophilic spot and use it as a miniaturized cell screening chip. Other details and examples of applications can be found on www.levkingroup.com