Investigating the role of glycosylation in multiple myeloma

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Video in TIB AV-Portal: Investigating the role of glycosylation in multiple myeloma

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Title
Investigating the role of glycosylation in multiple myeloma
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CC Attribution - NoDerivatives 4.0 International:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
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Release Date
2013
Language
English

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Abstract
All cells in the body are heavily coated with sugars, a process known as glycosylation. Changes in cellular glycosylation are a recognized feature of many cancers, such changes often being associated with more aggressive behavior and a tendency to spread or metastasize to distant sites. Until recently little was known of the role of glycosylation in the progression of the blood cancer multiple myeloma. Our work reveals that glycosylation-related genes are abnormally expressed in multiple myeloma. In particular, we have found that overexpression of an important glycosylation gene called ST3GAL6 is associated with more aggressive disease and poor prognosis in patients with multiple myeloma. We believe that ST3GAL6 may be a new biomarker of progression as well as a potential therapeutic target.
Keywords glycomics biochemistry
Glycosylation Multiple myeloma
Multiple myeloma Bone marrow Cell (biology) Cancer Antibodies (film)
Hematite Gesundheitsstörung Activity (UML) Radiation damage Chemical experiment Red blood cell Singulettzustand Butcher Screening (medicine) Wursthülle
Multiple myeloma Golgi apparatus Tumor
Multiple myeloma Ring strain Survival skills River source Life expectancy
Multiple myeloma Golgi apparatus Gesundheitsstörung Biomarker Genregulation Gene
Multiple myeloma Klinisches Experiment Survival skills Enzyme Risk factor Gene expression Gene
Bone marrow Kohlenhydratchemie Cell (biology) Singulettzustand
Bone marrow Seafloor spreading
Multiple myeloma Ice Golgi apparatus Gesundheitsstörung Biomarker Gene expression
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it's my name is michael the war on professor of hematology at the national university of art and always going to talk to you today about like cause a nation and multiple myeloma multiple myeloma a cancer of antibody producing cells called thousand cells in the bone marrow.
features of active disease including her red blood cell production kidney failure and bone damage its referred to as multiple myeloma because of the presence typically have multiple screens series of involvement approx twenty five new cases per hundred thousands of the population are diagnosed each year in europe intensive research.
research into the biology of multiple myeloma has revealed much about factors responsible for its development and progression which is great to be aided in the development of new therapeutic treatments for my little over the past decade there has been increasing focus on the supportive role of the tumor micro-environment and the success of new retire these have been.
partly due to their ability to target why themselves in its to my current vironment.
with improvements in survival in life expectancy the number of patients alive with my loan is rising and now constitutes an increasing strain on healthcare sources nevertheless despite these advances in therapy myeloma it remains incurable would survive in high risk patients less than three years more. over most patients eventually die of multiple myeloma also to steer that more effective treatments are needed we recently established research program to explore the role of like cars and nation in wild which until now has been a virtually unexplored aerial while my biology are starting hypothesis.
this was that there are significant differences in the genetic regulation of like consolation associated genes in my themselves compared to their normal counterparts these could play an important role in the development of the disease and these could potentially be exploited old as biomarkers and turkey targets.
we've identified like cause a nation genes that are normally expressed multiple myeloma his analysis has identified a number of potentially rather than genes not previously implication progression of wild.
we focused on a gene called s t three got six the product of this gene is an enzyme known as a silo transferees.
overexpression of this gene was associated with poor survival in a large clinical trial and multiple myeloma importantly patients over expressing these genes survived on average only three years compared to four years in patients not over expressing as to three got six these could not be explained. range while there are no risk factors.
so how might tested three got six effect prognosis in multiple wild. as to three got six is involved in production of a sugar known as silent newest acts.
we believe this sugar may regulate the filming of circulating miles cells to the bone marrow.
moreover it may also be involved in spread of my themselves to other tissues outside of the bone marrow this is associated with a very poor prognosis for the patient.
we believe that overexpression of ice to three got six may constitute not only a biomarker of multiple myeloma disease progression but also a potential therapeutic target.
we believe that these findings support our starting hypothesis that alterations and like as a nation may be important and disease progression.
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