3D-printed reactionware

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Video in TIB AV-Portal: 3D-printed reactionware

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Title
3D-printed reactionware
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CC Attribution - NoDerivatives 4.0 International:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
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Release Date
2012
Language
English

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Subject Area
Abstract
3D printing affords the laboratory chemist unprecedented freedom to design and fabricate bespoke chemical reactors uniquely designed for specific purposes. This video demonstrates the design process of creating 3D-printed reactionware, and describes how we have used these devices to control not only the chemical environment of a reaction (the incorporation of catalysts and reagents into the structure of the reactor) but also to use the architecture of the chemical reactor itself to influence the trajectory of chemical reactions. The use of this design and fabrication process gives chemists control over their chemistry by manipulating the geometry, topology and composition of their reaction vessel for specific applications.
Keywords flow methods
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Chemical reactor Chemical experiment Combustion chamber Mixing (process engineering) Chemical reaction
Chemical engineering Chemical experiment Operon Mixing (process engineering) Chemical reaction
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Chemical reactor Area Combustion chamber Chemistry
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Materials science Chemical experiment Base (chemistry)
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Chemical experiment Scaffold <Biologie> Click chemistry Transformation <Genetik> Polymer Silicon Polypropylene Chemistry
Chemical reactor Azo coupling Chemical experiment Asset Plant breeding Carbon (fiber) Stream bed Polypropylene
Chemical experiment Controller (control theory) Transformation <Genetik> Chemistry
Chemical reactor Activity (UML) Chemical experiment Chemical reaction
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Reaction mechanism Transformation <Genetik> Operon Chemical reaction Pharmacy Chemistry Process (computing)
Molecule Organische Chemie Chemical experiment Chemical reaction Chemistry
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i my name is the current in on the garden professor of chemistry of events of last year in the uk and today we're going to talk to about three d. printer printed reaction way literally how we can use three d. printers to make reaction to reactors in which we can do new chemistry now chemistry are classically to reactions in gloucester.
but also as a chemist best friend because you can take quick fit and you can make really nice elaborate architectures in which you can do reflexes additions and you can be very complicated synthetic manipulations so i went last question could be going from traditional glassware will say test tubes and somehow use.
from three different reaction were as we call it to do chemistry.
i'm giving the example of a device with mate made by three d. printing of what we're going to do today is explain to how we think about the reaction we want to do in terms of the sequence of edition of reagents the amount of the reagents the time for the reaction and then we design that reactor in three d. and then printed and what we've got here to cut away.
of the reactor way you can see two chambers carrying the agents in the mixing reactor and so what we've been trying to do is ask yourselves if there is that if we can do something new by printing the reactor and doing the reaction in the reactor because it allows us to configure the chamber's so that means we can change the volumes.
we could change the way in which these things mix and also the number of uni operations that you put together is almost like taking a chemical engineering approach to its molecular discovery and i think that's a really important idea can we take the reaction in the reactor and combine them together in a new way so we're not just thinking about the reaction.
separately to the reactor but with thinking about it together in device and these devices were calling reaction way.
but until kids and on the push talk researcher hear the university of glasgow were the core hundred i can talk a little bit but the design of three d. printing reaction where we start from a three d. digital computer aided design software package where we designed the architecture for reactors.
in this software it's easy to reconfigure the geometry of the reactors were producing as well as the design in features which can be printed in catalyst another chemical reagents to produce the correct chemical environment in each of the areas of the reactor for example here we've got three chamber reactor where we can.
design in the catalytic features to the inside of the device the chamber has the chemical environment necessary to conduct the reactions were wanting to perform.
once we have produced a three d. design in this software package we can transfer that designed to the software which controls or three d. printers where the design is translated into seven structure in for the three d. printing machines they instructions tell the printers where to place the different components hard to build the architecture.
and where to insert the catalytic the active and chemically active regions within the architecture moving from an initial design to a fully functional three chemical reactor one of the key advantage of this process is the ability to reconfigure the design of the reactor architecture based on exp.
or mental data so we can change the geometry of the reactor chambers or the chemical composition adding a new catalyst to new reagents based on the results of the previous experiments and so we can get rid the design of a reactor to optimize the reactors capabilities also we can control the reaction.
not only with the chemical environment of the chamber's but also the geometry these environment its current giving us an extra degree of control over the chemical synthesis.
hi i'm not science i'm a postal hear the crying and i'm going to show you some of the prince's that we have available.
so i just always printing at the moment we have the fab at home personal fabricated which extremes gel like materials layup by leia to build up three d. architectures at the moment its printing using base commercial bathrooms see that she might use to go around the sink in your.
all three to make it was a tight as.
and the printed prince with a range of muscles of different sizes.
it's so that we can get different resolutions on the things that we prince however.
the overall resolution that we get tends to be rather poll although the devices that we make a very flexible and it started with a needle they will sell fail.
it's the other printed that we have is this three touch and that prince solid thinks such as this party properly wire which will be fed into the machine and the machine melts them and then again extrusions lie abide by an additive fashion the molten palma on to the lab.
the low and then this solidifies very quickly at room temperature to give us a more robust devices that we can print a much higher resolution however this printer is limited to using inks that it can melt and then extruded whereas the fab at home will print anything. that we can get into the syringe and then squeeze out and indeed we can even put mixtures of things into a syringe and squeezing out which will talk about a little later.
it's. hello i'm ross for going on a research associate in the one lap and going to tell you but some of the reactor designs that we prepare three three d. printing so first stop but an example of a reactor where we can use geometric control to influence the outcome of the reaction so this is a cutaway every actor and you can see here.
we have every agent chamber for the my reaction takes place by changing the size of this chamber we can change so much of the reactions to reach into the chamber altering the stock you much of the reaction and selecting for certain products and we can also exercise chemical control so here i have a higher reactor that sept partly prepared.
and to make this we use the to printers that we have in the lab first lee we print scaffold using at polypropylene and secondly within the scaffold we include its silicon polymer into which we have embedded sack catalyst of choice to carry a chemical transformation so here we have a click.
catalyst that acts as an asset catalyst and here we have fat play the more carbon which can act as a catalyst for cross coupling or deductions so once we've fat printed in that the active catalytic bad completing the reactor with polypropylene we can complete had designed reactor here so by including a catalyst reagent bed to.
uncertain orders we can carry that sequential chemical transformations and in doing so i select the desired chemical products exercising this chemical control.
so we've talked you today about taking a chemical reaction and embedding it in a reactor not just doing and gloss but three d. printing the architecture which we do the reaction this is kind of interesting because this allows us to think about not just using a passive reacted actually embedding active free agents within their.
action way and so if you can imagine that we not we could do this not just here where we have three chambers but many changes side by side we could start to think about making really complex molecules in a single device and what i mean by that well in chemistry studio mitre is very important to tell us this is very important and also come into real.
screening and common and combining reagents and so in orders is very important the problem is that chemists very rarely think about the unit operations they do for discovery process a more think about the mechanism and the process of the transformation i think the reaction were was allowed us to combine thoughts about the chemical processing and this.
maybe they just want to make me molecules and this is what we are actively trying to do at the mall at the moment and i think the jury's still out on whether reaction that were will allow you to to really dramatically discover new molecules one thing is sure that using three d. printing reaction were will allow us to the chemistry organic chemistry beyond gloss way and this is.
a very exciting prospect of the future. i.
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