3D-printed millifluidic reactionware for synthesis and analysis

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3D-printed millifluidic reactionware for synthesis and analysis
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We utilize 3D design and 3D-printing techniques to fabricate a number of miniaturized fluidic “reactionware” devices for chemical syntheses in just a few hours. Starting from inexpensive materials we are able to produce reliable and robust reactors. Here we show a two-inlet reactor setup with pumps and in-line or on-line analytical techniques, such as IR spectroscopy, which is used to follow an imine condensation reaction, and mass spectrometry, which is used to characterize the complexation behavior of a cyclohexane-based ligand with copper (II) chloride.
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when you see you first continuously glasgow in the uk and we can talk today about three d. printing all the money fluid intake and microfluidic reaction way to say my hand here i'm holding a pulley proclaimed.
device so why would you try and build a mini fluidic device using three d. printer well microfluidic says now really well established in basic analytical chemistry and biology and is a really nice way of doing very low volume high precision high throughput analysis.
this and control of reactions and biological systems but the problem of microfluidic said one of the drawbacks of microfluidic so the fact it takes a few days to both design and make a device the interesting thing that we've been exploring him in my lab is the use of three d. printing to make devices much more quickly and.
unfavorably so what we want as if we could combine the the the use of three d. printing to print small devices like this and potentially design these devices in print and just a few minutes how can we do this what i've got my hands are set for is a pity it is a physical device made up polypropylene and on the screen hair have actually got us.
greedy picture of the three d. printer and in this case you can see the street printer the nozzle hair printing some material in the representation the sea on the screen and eye condition physically rotated and the thing that we want to get we're trying to do is to combine three d. designing chemical design in the same kind of thought processes so what does it.
his main for the fabrication and design of the device walk as you can see here with printed a device with the channels about a millimetre in diameter and you can say on the screen a nice photographic.
a cross-section way you can see that we've got these the cross sections around about eight hundred microns two millimeter we can go small up in the middle east is really very achievable and really rapid so what are the advantages and how would we how we go for the process of designing a device let me give you this example here this device always same got here.
years to inputs where we put two reagents and that say and a mean an audi hide for him in condensation and the materials will come together in reactor they would mix and then they would travel down this pipe of course will need this.
the length of to being here to hear to be long enough so that them the the region's a mixed and react and so the reaction is complete and what we will show you later in the online announces coming out as we can show if this is to farce actually or your measure here or your deserve an infrared is the audi hide in the number he acted how.
however if we slow down the flow rate and we make sure this length of shooting is long enough to give time for the reaction to occur and will see the product coming out this point here and so when you're imagining how you can make quite complicated devices you really need to think about how many reagents you putting end but if you need to put in more than one reagent it's no problem because you just.
add in another port ensure into your and your into reactor in which it will be in here so this allows you to really be quite creative and configure the vice go to the computer design device you want printed very quickly and then tested and this is a real power of using the combination of cad and three d. printing together because. we can typically make these devices in just a few hours even minutes if we if we make them small enough and so what we can then do and what we will show you today is not only be controlled the inputs but we can also control the outputs and put the outputs into online analysis and this allows us to then and initiate and composer.
and both control and observe the reactions and as you can see the complexity of the system is is limited only by your imagination and physically how many bits you can you can add into the device so i think that the the the future for this is all we have to be configured are micro reaction were in a. fleet in a way and this will open up people's minds in to designing not just new reactions but new reactors in which to do those reactions and i think that is probably a a slightly new perspective in synthetic chemistry were before we normally except a expect the reactor to be a passive. and titty where is now we can really designed the shape where the inputs are where the output saw and so we really going beyond what we have been made in a normal microfluidic foundry all in the laboratoire were using robots loss.
and phil kids in a postdoctoral researcher at the university of glasgow working in the current group i'm going to the little bit about how we go from a digital design to three printed chemical reactor first we use a freely available computer aided design software package to produce a digital file which contains the three.
the architecture of the device were going to print for example here i've got standard microfluidic type of device designed with two and puts on one put for the reaction product once we've produced this three d. file we can take a file through to our three d. printing software which.
the analyzes the in three d. file on produces a an instruction file for the three d. printer which gives the machine all the information it needs to produce the three d. device from the digital file many now i am i as a reset chair and make it a trestle each have been at the university of glasgow.
this year is asked to detach printer which trance a devices in a layer by layer fashion depending on the belt file the printer were expects treating a polymer in this case play propylene the hot no souls as temperature at about two hundred ten degrees celsius we use play for a plane because as robust as.
a much chemically in art the resolutions that are printing with here in the x.y. direction point two millimeters as and in this said that action it's playing two hundred and twenty five millimeters as friends of friends like iraq first and then print a layer by layer a building also devised.
depending on from the old file and at the end you have your device depending on that design that you pay in at the ends we have the inputs and their pets which have been made as sites that matches the m..
commercially available plastic connect us which i made a slightly harder plastic and this is a very question especially to do and there's no leaks and it means that you can connect the inputs and the outfits to death from palm os and online analytical techniques.
moose because some sumo serve so soothing the growing group i'm going to show you go is simple east to integrate the three the green didn't react to news in the real flow system these propose you can see here the reactor that we yesterday the printed and i.
we did with them that free things and connected to us at the pumps and then in line and analytical techniques such as a flow.
the bumps have the proposed to jenny the pressure that are necessary to push the substrates through the reactor then to the line and only takes and then to the collection point seems we have the created the reactor with unknown volume the flow rate of the bombs with that in mind that i see this.
time of the substrate inside that react to what means that time they subside we have to meet each other and react the height of the flow rate the lowest level since them and therefore know what the action time and know what combustion will be obtain this is all mission by. they a line which is becoming and technique inorganic chemistry because if the lowest the money thought characteristic bounce from the product and from the substrate in real time in this way we can know what's happening in a reactor and optimise the conditions to maximize the youth or the to obtain. and kinetic by me to have such a scheme that the cost as the key media information and so on. they were going to create some by a selected as an example he said it is simple seen this is so fun the mean coming from the been selling high.
and they've been sealed him. reaction is cut about the ethanol as a solvent what the sentiment family friendly somen and the brother of the reaction is very convenient because it has said the financial.
and correctly stick i ever been compared to this that the material has said peak at around seventeen on the way for numbers.
and the product has a band at the around sixteen and that for the way from.
in this way by comparing the intensity of ball bounce we can assess the progress of the reaction in real time.
the bomb said control be a love you so it's very simple the us make them brown with a brother to the final sequence.
here we can see how they ben stiller mine and then select i had a mixed that relatively high flow rate which will generate yes we couple seconds over assist time in the reactor and therefore will have served mostly and and reacted been selling high the missile i mean in they.
i am. once a bomb said upon. running again very simply going to the idea when this is the owner of different flow rates we can very quickly.
show how at lower flow rates would have hired a serious time and mostly will set of the bond assisting hundred forty corresponding to the mean and no one could responding to their high therefore this means that their reaction has been completed of this flow rate but as we increase the.
no rate we have said how the drug that is less intense and that is higher been from they've been some the by what means that the reaction is not complete.
oh and also tend to last a aspect to expand its own and watching he added same complaint season reaction of the tentative eggs.
came we are so intelligent solutions sulfites like a scene beings likens corporate quite so.
so we flew them together into the season and to face and of a city actual tea leaves building footage aleutian fees here since our problem.
came from that same tepees bidding will just left the base we need this less developed because the saudis of the my space is playable.
also hear the splits are where we can maintain called solution for for the best early season of the project.
wrestling into latest a mass spectrometer hotel the bills able to be should also called.
it so today you've seen that using the approach of designing reaction were using three d. printing that you going from a computer model can add to the physically print printing the device and then connecting up the device so you can do the reaction in this case there and a mean and i mean cost now to her.
my to give you the main and so when you're trying to implement the the chemical process in device you have to think in a slightly different ways you would if you just doing and stand around bomb last for me this is one of the exciting developments in organic chemistry we are now so good at making molecules in designing all sorts of new approaches to making very.
complicated skeletons i wonder how we can use this type of device architecture is to try and take that knowledge and use architectural control now not just at the them the mini fluidic level but also in a three d. is printed space and this is just a very small step along that along that path.
you can imagine building up the device in a number of dimensions now give your market an example here so this is a grid device where we can have three inputs here three inputs here three outputs here but what we've done is we've got a concert where with making them stackable and so you can take one device and stacked on top of another.
rather like this and you can imagine doing a whole matrix of reactions in this button device and then his top device and connecting them together. so this allows us to think about putting of ray chemistry into the three d. device but i think we should just go to raise we should go beyond to look at really complicated reaction steps and embed them into the reaction were using this approach an important thing is we need to combine not only on the village.
of organic chemistry which of course is vital but on the edge of chemical engineering kinetics but also we now need to start to design are actors and this is perhaps a slightly new way of thinking them before and you know although glassware is extremely important in chemistry and a very very good.
from underpinning way of doing reactions we maybe i think beyond loss and how we can print our own reactors and devices.