The ubiquitous human pathogenic Acanthamoeba castellanii can cause severe brain or eye infections like Acanthamoeba keratitis (A. keratitis), which occurs mainly due to wrong contact lens use and can lead to complete vision loss. For immune suppressive individuals it can even cause a granulomatous amoebic encephalitis (GAE). Therefore, research on soft polymers comparable to contact lenses are carried out to investigate the pathogenicity of these amoebae and to develop strategies for avoiding infections with these parasites.