The video describes the discovery of mbandakamine A, a dimeric naphthylisoquinoline alkaloid isolated from a ‘new’, botanically yet undescribed Ancistrocladus species. This liana grows in the tropical rain forest of the Congo Basin – and has now been cultivated for the first time in the greenhouse of the Botanical Garden of Würzburg: a worldwide unique cultivation success. The absolute stereostructure of mbandakamine A was elucidated by modern spectroscopic methods like MS, NMR, and CD (circular dichroism), in part hyphenated with HPLC, and was confirmed by quantum-chemical CD calculations. Besides its novel structure and the unprecedented biosynthetic origin, mbandakamine A also shows good activity against the malaria parasite, which was determined in the SFB 630 network, involving scientists from chemical, pharmaceutical, biological, and medicinal research groups.