In 1990 the first single atom manipulation experiments were carried out with a scanning probe microscope. The video describes how today, 25 years later, a motion tracking system is used to couple the microscope tip directly to the operator’s hand. Literally moving the tip with their hand, the operator creates a nanoscale structure by removing molecules from a monolayer, although the molecules are bonded strongly to their neighbours. The experiment illustrates the power of intuitive control and demonstrates the possibility of intentional manipulation even when the interactions between the manipulated objects are largely unknown. Music by Alexander Lubeckij (Musiklizenzvereinbarung)