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Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

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Logo of Beilstein-Institut zur Förderung der Chemischen WissenschaftenBeilstein-Institut zur Förderung der Chemischen Wissenschaften
 Breen, Jessica R. Yufit, Dmitrii S. Howard, Judith A. K. Fray, Jonathan Patel, Bhairavi Sandford, Graham

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Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination
Alternative Title
Fluorination in flow
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163
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CC Attribution - NoDerivatives 4.0 International:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
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Abstract
4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid–liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.
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