UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:06:34 Terpene 0:08:55 Biogenic Head-To-Tail Synthesis of Terpenes 0:14:41 Protein Prenylation: Localizes Protein to the Membrane 0:18:03 Bisphosphonate: Anti-Osteoporosis Drugs 0:20:27 The Rich Structural Diversity of Terpenes 0:34:51 Cyclization of Isoprene Oligomers 0:39:51 Control Over the Central Dogma 0:42:22 Ancient Small Molecules with Bioactivity 0:46:08 Arrows in Chemistry and Biology 0:49:11 Cell Signaling Scenarios 0:54:50 The 7 Signaling Pathways 0:56:16 Genetics to Dissect Complex Biology 1:01:06 Small Molecules Offer Control Over Otherwise Unavailable Phenotypes 1:07:48 Nuclear Hormone Receptors 1:18:14 In Vivo Biosynthesis of Calcitriol 1:19:23 Restoring Biological Function of a Mutant Vitamin D Receptor