Lecture 07. DNA, RNA, and Cancer.

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University of California Irvine (UCI)

Weiss, Gregory Alan

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Title

Lecture 07. DNA, RNA, and Cancer.

Alternative Title

Lec 07. Introduction to Chemical Biology -- DNA, RNA, and Cancer

Title of Series

Chemistry 128: Introduction to Chemical Biology

Part Number

Number of Parts

Author

Weiss, Gregory Alan

License

CC Attribution - ShareAlike 3.0 Unported:
You are free to use, adapt and copy, distribute and transmit the work or content in adapted or unchanged form for any legal and non-commercial purpose as long as the work is attributed to the author in the manner specified by the author or licensor and the work or content is shared also in adapted form only under the conditions of this

Identifiers

10.5446/18866 (DOI)

Publisher

University of California Irvine (UCI)

Release Date

2013

Language

English

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Subject Area

Chemistry

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Lecture

Abstract

UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:06:40 DNA Chemistry 0:09:48 Cutting and Pasting DNA 0:18:42 Protein Modification by PCR 0:23:15 UV from Sunlight Cross-Links Thymines 0:25:09 E. Coli Photolyase 0:26:36 Protecting Your Cells By Sun Screen 0:33:24 Cells Must Advance or Die 0:34:57 DNA as a Big Nucleophile 0:39:51 N-nitrosoamines = Ptent DNA Alkylating Agents 0:45:00 Known Carcinogens 0:47:44 Paradox: Cause and Cure? 0:50:42 Excision Repair in Humans 0:57:25 Hundreds of Mutations Required to Cause Cancer 1:03:57 Sir Percival Pott 1:05:19 Testicular Cancer 1:06:56 P450 Substrates as Potent DNA Alkylators 1:08:24 Benzopyrene: Pro-Epoxide DNA Alkylators 1:10:18 Toxins from Molds Growing on Grains 1:11:36 Nitrogen and Sulfur Mustards 1:13:35 The Re-Evaluation of RNA's Importance