Lecture 07. DNA, RNA, and Cancer.

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Lecture 07. DNA, RNA, and Cancer.
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Lec 07. Introduction to Chemical Biology -- DNA, RNA, and Cancer
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Weiss, Gregory Alan
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UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:06:40 DNA Chemistry 0:09:48 Cutting and Pasting DNA 0:18:42 Protein Modification by PCR 0:23:15 UV from Sunlight Cross-Links Thymines 0:25:09 E. Coli Photolyase 0:26:36 Protecting Your Cells By Sun Screen 0:33:24 Cells Must Advance or Die 0:34:57 DNA as a Big Nucleophile 0:39:51 N-nitrosoamines = Ptent DNA Alkylating Agents 0:45:00 Known Carcinogens 0:47:44 Paradox: Cause and Cure? 0:50:42 Excision Repair in Humans 0:57:25 Hundreds of Mutations Required to Cause Cancer 1:03:57 Sir Percival Pott 1:05:19 Testicular Cancer 1:06:56 P450 Substrates as Potent DNA Alkylators 1:08:24 Benzopyrene: Pro-Epoxide DNA Alkylators 1:10:18 Toxins from Molds Growing on Grains 1:11:36 Nitrogen and Sulfur Mustards 1:13:35 The Re-Evaluation of RNA's Importance
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story with the freezing either side of the tracks were laid by giving them all the time she contends that when we look at cancer cells we find hundreds if not thousands of indications unit start sequencing tumors we find the tremendously European beaches and a rich tumor is slightly different and furthermore biopsies difference what's this into we also find tremendous differences amongst themselves which otherwise provisionally look like that so too were the answer requires hundreds if not thousands of Haitians you know takes an enormous change you need to work on those occasions after partying Regeneron control aspects of the self and I like to think of these as accelerator on watch and rates of Okada said reveals that only works really well founded right stations might not know that the the program will be held lunch that flight was this extra power help and that you put down to switch gears and earlier I should you that sales have progressed through the cell cycle and that your checkpoints through that cell cycle so I'd like to see the checkpoints actually the here as itself cannot share because we didn't the self-titled the cannot proceed however the communications to the cat points to the producer controlling the tests were not consulted about the rest the end of mutations that allow itself is the rest the cell cycle allowing runway solid so those indications much which checkpoint proteins involved in cases of also cells have on salsa growth factors and that receptors which are responsive to the external part of the group backed out of our house requires that the region's accelerated the growth factors in helping to sell stock to buy stock the next start doing it going on so that the occasion the accelerator and finally but all cells had tumors of strategy looking only 1 or 2 3 which I like to to think that breaks this is the use of the machinery that just down the sale of 1 of the 1st round of full and when this happens these tumors that threatened to trigger apoptosis or cell suicide that prevents him so the of the companies relations have after that all 3 of these pathways just 1 is that is a good chance that sells for about this and progress to prevent cancer among other here and in the occasional really than having start running out of the car so let's see if we take it very close to that of the 3 which is the tumor suppressor proteins of heroes some years the self-destruct button and there are a whole series of different questions some constantly asking people were going to sell division at any given time answered the question is do you not representative of the unit is being probably 1 of the insurers know that on the basis that albeit usually centered apoptosis were recently letters of foreign lenders fancier works were at its 1st meeting and the loss of a lot to of that someone is really going so good the recent sensors that turn on us and mutations in the gene allowed the damaged initially said beating you 3 or more are bound to make 60 per cent of the Holy See this is a very very confident that the stations that are running a large number of the people that it's almost the workers in the game is not good 3 was shut down because of the runaway acceleration that life in excess of
and I know that you did that's the really serious and for example the site is available in the region he said 3 directly from the book itself irascibility his chances in the interview qualification 3 this is literally the smoking gun that this is what is believed to be inserted into the and smoking which until recently was the leader of the United Nations so that can get the cigarette companies were able to cigarettes saying there is no doubt that it's best to call on here is that
what happens in the communications the residents there are highlighted in yellow the easier it is there that have positive charge and interact with the whole family shows that he agreed that while the result was that it was quite important is active transcription factors to try and get the positively charged residues of meeting that the 3 can no longer willing to DNA and no longer trigger opposite smoking that really it patients specifically at the molecular level to these residents here that the results against yourself down should stop you people or something she persuaded stop at nothing to anything worse my father died of lung cancer and passionate stopped smoking you might as well be put you on the way to the loss of possible something the region that right now was about smoking that causes cancer we actually know quite a bit about wife is 1 of the sport's cancer and was back a long way so long history biology and against the bill back to the other ideologies that rates of personal loss of personal hot humid here was positioned in London and Cheney Street at a ridiculously high levels of visiting the use of the army in the central London correctly .period intentionally and the associated costs is that we don't know about you but I wanted to be with you about it during like that and it would be covered in it there in the chilly results another Bloomberg said based on what we find work chemicals that cause testicular cancer and other types of cancer and
I think you have to stick with him and that's why I'm sorry that you have divergent views a variety of convinced by showing we never knew what questions Sunday is the some of the prevented 1 person brought in from the Gulf for of 1 person to answer directly overhead so that
here is a picture of the cross-sectional view the site of the centimeters of this already living here in it is this 1 day on the computer and securities analysts tremendous growth of cancer the students using hospital is going traders and this is the sort of thing that we have generally been stocks fall I was in he also surgery and so on and and we should all be thinking about monthly self exams and get more raised here again this is the announces that I really hope so they prevented us over time the company said it had secured a vote the level of warrior and these are actually she's a conference highlighted here Florida but against voluntary excerpts serviceable smallpox is noticing that London very high percentage of Chile's coming down with the cancer testing and wondering what is it about this new review homicides that this is not a positive testing cancer in actually means we now know that I couldn't Burns Harbor and burn stuff but there are a lot of procedures demonstrated that so this then fiery was founded by concentrations in the Bloomberg survey so now I see that as a share of the operation to remove it the governor of the current state of the of the American College of Art and the cost of this so for example the and fiery anywhere on the back side of the last finally come down these horrible incident lesions the books of the year and the work of these work by members of the ingredients register black aromatic compounds housing flats guests on 3 Stewart 1 2 3 Turkey where the accident last man on the video last week the like that the additions also out with you and this is less obvious actually is what is the use of cigarettes work without having to to the division of Europe and burn it in his own words that our fans of Harry and offensive I
that you will liver is I'm not sure it's your liver bullfighter processes such as the International this that is not very soluble in water is really bad news have insoluble fragments of stuff floating around blistering social lives the best in the office and deliver strategy for soluble and insoluble is oxidized and item functionality that would be insoluble in water and so here it is a year is inside the Labour Officer lies in the hands of fiery here's a successful operations in made while was the 2nd observation factories and I'll pop side I has a strained remembered during this streams three-member rate is fantastic electrified this analysis is really bad it's now have this this internal later that's why didn't you find that it has the perfect properly electrified delivered right up against during political unity and actually call this is an enormous problem there is a new beginning this month by local only by this Parliament is hiring this reason but you don't country that people were used to have a lot of work on this and I can't come down with a lot of stuff lately because of something that of very by your goal should be to try to eliminate the barriers such as possible losses that didn't work paranoid about everything that appears on the agenda it about you and here's something you can do to help yourself a little while longer simply by avoiding the problem here is that
a lot of this is it this is how the accident happened hostilities the final that growth really like units united States although he is testing war in the presence of this small hospitals passenger was spiritualists reversible but the countries where the public political health systems on the others were you seeking his part as vigorous and this is more of a problem but the problem is that ball like this and use all this happened after which again is multiplied by by cytochrome working the all is the site of the work In the
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right on the spot and genocidal itself earlier I showed you I found that and I can get at the root of acquiring years of very perhaps silver instead it it was the 1st time that it would river ,comma that is that which we however at the center of the connectors and by the warmth and electrify tendencies in English while tax and how it is you will find the alleged in the beginning he possibly giving you history and there will be only will get taste real refugees for example and we will use all over the compound I told the rest of the world .period is in use in Europe so these were also used as a word that I will what just would using you actually get used to the time that the case studies ,comma counterparts cancer by wearing fantastic electoral violence which then reacts with nuclear plant in the files found in the EU OK so then here is
the nitrogen mustard equivalent of these compounds that we saw earlier in in the day and all of those who commented on the basis that is directly in line the here and this electrified officers right with nitrogen as positive charge on the east side of the truck so we literally the attacks electrons and constantly to the positively charged nitrogen said that the purpose of the perfect electrified modifying on the questions about the nature most mysterious so musters the obligation the
only I wanted years of the people 5 minutes to start talking about it on the distant as we we talk about how the far it is going to be the right questions about the set on fire in the allowed for 2 recognized on tremendous support in stock in the south of the town as an example of this this is actually a structure that you have positive on he is the 1 which was annexed by end of you know this is around me when years and structural unit part was not very well understood as positive that structure was with the structure of the costs wholly wrong regularly cracked structure you but along with the writing is on the also signs handlers by the sugars in the absence of any specific mention dioxin like you and also figured out units in the side of things on it so it's possible signs of cooling brought against some details correct that this structure was
politically not rightfully worried unitary circle over the years we will work closely with you you start to find an alternative to the beaches of example that the bases are being held on 1 of the bombs the size of the backbone of the year by the crime itself so in a similar way we must have a re-evaluation of the importance of Oregon when it was originally discovered it was to you transfer service go-between between units at the end of the last 20 years of our appreciation of parties you itself has expanded enormously so
you have to know there are a lot of soldiers sailors here on hand 1st as soldiers it's actually a very palace for I don't think it's going to actually go out the sequences of other currencies as a silly things wrong Bloomberg said the lessons writers of appears headed firmly lingering and Europe's or the answers Europe's during the writers of the proceeds as you're right right is already held that the existing size for a binary 5 necessarily experience so parties the wall at the end of this season will be back on Tuesday will have a lot of talk about "quotation mark


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