Lecture 17. Terpenes and Cell Signaling, Part 1.

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Identifiers

10.5446/18876 (DOI)

Publisher

University of California Irvine (UCI)

Release Date

2013

Language

English

Content Metadata

Subject Area

Chemistry

Genre

Lecture

Abstract

UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:06:34 Terpene 0:08:55 Biogenic Head-To-Tail Synthesis of Terpenes 0:14:41 Protein Prenylation: Localizes Protein to the Membrane 0:18:03 Bisphosphonate: Anti-Osteoporosis Drugs 0:20:27 The Rich Structural Diversity of Terpenes 0:34:51 Cyclization of Isoprene Oligomers 0:39:51 Control Over the Central Dogma 0:42:22 Ancient Small Molecules with Bioactivity 0:46:08 Arrows in Chemistry and Biology 0:49:11 Cell Signaling Scenarios 0:54:50 The 7 Signaling Pathways 0:56:16 Genetics to Dissect Complex Biology 1:01:06 Small Molecules Offer Control Over Otherwise Unavailable Phenotypes 1:07:48 Nuclear Hormone Receptors 1:18:14 In Vivo Biosynthesis of Calcitriol 1:19:23 Restoring Biological Function of a Mutant Vitamin D Receptor