Lecture 13. Protein Function and Enzymes.

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Identifiers

10.5446/18872 (DOI)

Publisher

University of California Irvine (UCI)

Release Date

2013

Language

English

Content Metadata

Subject Area

Chemistry

Genre

Lecture

Abstract

UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:00:41 Enzymes 0:03:20 Repeat Proteins 0:05:16 Equilibrium Constants 0:06:25 Enzymatic Catalysts = Catalytic Receptors 0:07:03 Michaelis Constant for Measuring Catalysis 0:15:30 The Perfect Enzyme 0:21:29 Kinases: Phosphorylation of Ser/Thr or Tyr 0:34:19 Why Study Single Molecules? 0:37:44 How to Follow Enzymatic Catalysis with Single Walled Carbon Nanotubes 0:41:34 Single Biomolecule Bioelectronics 0:44:24 Before and After Enzyme Attachment 0:46:29 Watching cAMP - Dependent Protein Kinase A 0:49:18 Further Generalization: Protein A Kinase 0:55:55 Lysozyme as a Model Enzyme for Glycosdie Hydrolysis 1:08:22 Proteases Cleave Amide Bonds 1:12:37 Regulation of Proteases Through Pro-Enzymes