Lecture 06. DNA Reactivity with Small Molecules.

CC Attribution - ShareAlike 3.0 Unported:
You are free to use, adapt and copy, distribute and transmit the work or content in adapted or unchanged form for any legal and non-commercial purpose as long as the work is attributed to the author in the manner specified by the author or licensor and the work or content is shared also in adapted form only under the conditions of this

Identifiers

10.5446/18865 (DOI)

Publisher

University of California Irvine (UCI)

Release Date

2013

Language

English

Content Metadata

Subject Area

Chemistry

Genre

Lecture

Abstract

UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:01:53 Examples of DNA Intercalators 0:04:21 How to Measure and Calculate the Strength of DNA Hyrbidization 0:09:20 Short Stretches of DNA & RNA Can Also Fold 0:10:31 DNA is Wound into Supercoils 0:15:53 Bacterial DNA is Stored in Plasmids 0:18:29 Antibiotics as Selection Markers 0:22:24 Eukaryotic DNA is Wrapped Around Nucleosomes 0:27:24 Trapoxin as a Highly Specific HDCA-1 Inhibitor 0:28:49 Biological Polynucleotide Synthesis 0:32:07 DNA Polymerases 0:46:57 RT Inhibitors 0:52:15 A Brief HIstory of Chemical DNA Synthesis 0:57:01 The DNA Microarray 1:02:09 FK506 Fingerprinting 1:03:58 Analysis of DNA by Electrophoresis 1:07:55 DNA Sequencing Uses DNA Synthesis 1:10:37 DNA Biotechnology