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Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages

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Title Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages
Alternative Title Makrophagen - HIV-induzierte Synzytienbildung bei humanen Monozyten/Makrophagen
Author Briesen, Hagen von
Rübsamen-Waigmann, Helga
Kreutz, Marina
Andreesen, Reinhard
License No Open Access License:
German copyright law applies. This film may be used for your own use but it may not be distributed via the internet or passed on to external parties.
DOI 10.3203/IWF/C-1815eng
IWF Signature C 1815
Publisher IWF (Göttingen)
Release Date 1993
Language English
Producer IWF (Göttingen)

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IWF Technical Data Video ; F, 10 1/2 min

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Subject Area Medicine
Abstract With the help of time-lapse phase contrast photography (1:200 to 1:6000) it is possible to follow HIV-induced cell fusion and the formation of syncytia in monocyte/macrophages isolated from human blood. Syncytia are rarely seen in normal cell culture. The infection of monocyte/macrophages by viruses, for example human immunodeficiency virus (HIV), induces fusion between these cells which results in large multi-nucleated syncytia. In HIV-infected macrophages that have been in culture for a number of weeks these syncytia can reach a significant size and contain dozens of nuclei. The film further demonstrates not only the formation of syncytia through HIV-induced cell fusion, but also specifically the dynamics of this process, the kinetics of cell fusion and syncytia formation as well as the nature of the involvement of macrophage subtypes.
Keywords cytopathic effect (CPE)
monocytes
macrophages
mononuclear phagocyte system (MPS)
syncytia
giant cells
HIV
cytopathological effect

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