We're sorry but this page doesn't work properly without JavaScript enabled. Please enable it to continue.
Feedback

Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages

Formal Metadata

Title
Macrophages - HIV-induced Syncytia Formation in Human Monocytes/Macrophages
Alternative Title
Makrophagen - HIV-induzierte Synzytienbildung bei humanen Monozyten/Makrophagen
Author
License
No Open Access License:
German copyright law applies. This film may be used for your own use but it may not be distributed via the internet or passed on to external parties.
Identifiers
IWF SignatureC 1815
Publisher
Release Date1993
LanguageEnglish
Other Version
Producer

Technical Metadata

IWF Technical DataVideo ; F, 10 1/2 min

Content Metadata

Subject Area
Genre
Abstract
With the help of time-lapse phase contrast photography (1:200 to 1:6000) it is possible to follow HIV-induced cell fusion and the formation of syncytia in monocyte/macrophages isolated from human blood. Syncytia are rarely seen in normal cell culture. The infection of monocyte/macrophages by viruses, for example human immunodeficiency virus (HIV), induces fusion between these cells which results in large multi-nucleated syncytia. In HIV-infected macrophages that have been in culture for a number of weeks these syncytia can reach a significant size and contain dozens of nuclei. The film further demonstrates not only the formation of syncytia through HIV-induced cell fusion, but also specifically the dynamics of this process, the kinetics of cell fusion and syncytia formation as well as the nature of the involvement of macrophage subtypes.
Keywords
IWF Classification
German
German
English
English