Different Keratinocyte Cultures - Effect of Liposomes and Dithranol

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Video in TIB AV-Portal: Different Keratinocyte Cultures - Effect of Liposomes and Dithranol

Formal Metadata

Title
Different Keratinocyte Cultures - Effect of Liposomes and Dithranol
Alternative Title
Verschiedene Keratinozyten-Kulturen - Wirkung von Liposomen und Dithranol
Author
License
CC Attribution - NonCommercial - NoDerivatives 3.0 Germany:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal and non-commercial purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
Identifiers
IWF Signature
C 1804
Publisher
Release Date
1993
Language
English
Producer
IWF (Göttingen)

Technical Metadata

IWF Technical Data
Video ; F, 16 min

Content Metadata

Subject Area
Abstract
Verglichen werden zunächst Kulturen von Meerschweinchen-Keratinozyten, menschlichen Keratinozyten (nach Subkultivierung) und HaCaT-Zellen (immortalisierte Zellinie). An HaCaT-Zellen wird der Einfluß von liposomalen Phospholipiden und Anthralin untersucht. Es ergibt sich, daß liposomale Phospholipide keine erkennbare zytotoxische Wirkung haben, daß dagegen Anthralin bei hoher Dosierung deutlich zytotoxisch wirkt und bei niedriger Dosierung vor allem mitoseverlängernd.
Comparison of guinea pig keratinocytes, human keratinocytes (after subculturing) and HaCaT cells (immortalized cell lines). The HaCaT cells were tested under the influence of liposomal phospholipids and anthralin. The results prove that liposomal phospholipids have no recognizable cytotoxic effect, and that higher dosages of anthralin have a clearly cytotoxic effect, whereas lower dosages work to extend the mitotic state in time.
Keywords Keratinozyten HaCaT-Zellen Epidermiszellen Dithranol Cignolin Anthralin anthralin cignolin dithranol epidermal cells HaCaT-cells keratinocytes
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