Protein synthesis on the endoplasmic reticulum
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| License | CC Attribution - NonCommercial - NoDerivatives 3.0 Germany: You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal and non-commercial purpose as long as the work is attributed to the author in the manner specified by the author or licensor. | |
| Identifiers | 10.3203/IWF/C-12768eng (DOI) | |
| IWF Signature | C 12768 | |
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| Production Year | 2001 |
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| IWF Technical Data | Video-Clip ; F, 1 min 21 sec |
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Transcript: English(auto-generated)
00:05
The synthesis of proteins destined for the cell surface and those that pass into the lysosomes occurs on the rough endoplasmic reticulum. On the ribosomes, RNA is translated into proteins.
00:20
Whether or not a ribosome is bound to the endoplasmic reticulum is determined by a signal sequence at the beginning of the newly synthesized protein. This sequence transports the protein being produced through the membrane. Transmembrane proteins contain several hydrophobic regions which embed themselves in the membrane.
00:45
The process is simplified in this presentation. For every two passages, a new channel is formed. Some proteins are glycosylated and this glycosylation is modified in the endoplasmic reticulum and in the Golgi apparatus.
01:06
Membrane proteins in the endoplasmic reticulum are pinched off in vesicles and reach the plasma membrane via the Golgi apparatus.