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Production of Purified Clostridia Toxoid Vaccines by Cascade Ultrafiltration

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Formal Metadata

Title Production of Purified Clostridia Toxoid Vaccines by Cascade Ultrafiltration
Alternative Title Herstellung von gereinigten Clostridia-Toxoid-Vakzinen durch Kaskadenultrafiltration
Author Seifert, Horst S. H.
License No Open Access License:
German copyright law applies. This film may be used for your own use but it may not be distributed via the internet or passed on to external parties.
DOI 10.3203/IWF/C-1560
IWF Signature C 1560
Publisher IWF (Göttingen)
Release Date 1984
Language English
Producer IWF
Production Year 1984

Technical Metadata

IWF Technical Data Film, 16 mm, LT, 125 m ; F, 11 1/2 min

Content Metadata

Subject Area Medicine
Abstract Vakzineherstellung zur Verhütung von Anaerobierinfektionen in den Tropen: Differenzierung von pathogenen Clostridien mit Hilfe der Dampfraum-Gaschromatographie. Anzüchtung der Bakterien im Fermenter, Toxingewinnung durch Kaskadenultrafiltration, Kontrolle der Toxinaktivität. Impfung.
A system is described which consists firstly of identifying pathogen anaerobes in tropical grazing lands by means of GLC and biometrical comparison of metabolically produced fatty acid patterns with such of known reference strains. Locality specific anaerobes may then be continuously cultivated in an especially designed bioreactor and their toxins separated through ultra-filtration. The filtration process is a continuous two step procedure. At first the microbes are separated from the spent broth with a hollow fiber of approx. 1 Mio. NMCO and in the second stage the toxin is concentrated and freed of allergenic peptides with a hollow fiber filter of 20.000 NMCO. The highly concentrated formalinized toxoid may be applicated intradermically beside the tail of the animal in a volume of 0,25 ml with a dermo-jet.
Keywords Ultrafiltration
Impfstoffe
Schutzimpfung
Fermenter
Dampfraum-Gaschromatographie
Chromatographie
Clostridien
Vakzine
Vakzineherstellung
vaccine production
vaccine
clostridia
chromatography
gas chromatography
fermentor
vaccination
vaccine
ultra filtration

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AV-Portal 3.8.0 (dec2fe8b0ce2e718d55d6f23ab68f0b2424a1f3f)