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Strahlenschädigung menschlicher Krebszellen in der Kultur - Portio-Carcinom, Stamm HeLa


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Formal Metadata

Title Strahlenschädigung menschlicher Krebszellen in der Kultur - Portio-Carcinom, Stamm HeLa
Alternative Title Radiation Damage to Human Cancer Cell Cultures - Portio-Carcinoma, Hela Strain
Author Gärtner, Henriette
Peters, Karl-Wilhelm
License No Open Access License:
German copyright law applies. This film may be used for your own use but it may not be distributed via the internet or passed on to external parties.
DOI 10.3203/IWF/C-875
IWF Signature C 875
Publisher IWF (Göttingen)
Release Date 1964
Language German
Producer Universität Tübingen, Medizinisches Strahleninstitut
Production Year 1963

Technical Metadata

IWF Technical Data Film, 16 mm, 195 m ; SW, 18 min

Content Metadata

Subject Area Medicine
Abstract Darstellung strahleninduzierter Effekte an HeLa Zellen in vitro unter Verwendung von Orthovolt-, Telecobalt- und Elektronenvoltbestrahlung. Die sichtbaren Zellveränderungen unterscheiden sich kaum voneinander. Nach Bestrahlung kommt die Teilungstätigkeit zum Erliegen. Zellverfettung, Chromosomenbrückenausbildung, Riesenzellbildung, Zytoplasmafragmentation, Zelltod.
Radiation effects on HeLa cells were recorded cinematographically, using the phase contrast process. Single doses of conventional X-rays (180 kV), high energy electrons (15,8 MeV) and cobalt 60 gamma rays (1,17 and 1,33 MeV) were administered. Radiation dose ranged from 500 to 4000 R, using a dose rate of 100 R/min. It can be demonstrated that the morphological changes after radiation damage scarcely differ with regard to radiation quality. Cell proliferation stopped almost immediately and cell death gradually increased after irradiation. Cells which were irradiated in early mitosis showed considerable morphological changes caused by radiation damage: chromosome bridges during anaphase, incomplete cell division, increase formation of multinuclear and giant cells, spontaneous cell death.
Keywords Krebszellen
Zell-Linie / Strahlungseffekte
Strahlentherapie / Grundlagen
carcinoma of cervix
cervical cancer
cell line / radiation effects
radiation injuries
HeLa cells
radiation therapy / principles
cancer cells

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