The mission of the Helmholtz Open Science Office is to promote the cultural change towards open science. The office, established by the Helmholtz Association in 2005, sees itself as a service provider that supports the community in shaping the cultural change towards open science. Guided by the motto "Enabling open science practices in Helmholtz!" the Helmholtz Open Science Office works within the Association and promotes the visibility of Helmholtz on a national as well as international level within the context of Open Science in the spirit of the Helmholtz mission. Regularly occurring workshops, lectures, discussions, and publications provide information on the opportunities and challenges of open science.