We're sorry but this page doesn't work properly without JavaScript enabled. Please enable it to continue.
Feedback

Slow down to speed up (summary of "Delay-facilitated self-assembly in compartmentalized systems")

Formale Metadaten

Titel
Slow down to speed up (summary of "Delay-facilitated self-assembly in compartmentalized systems")
Autor
Lizenz
CC-Namensnennung 3.0 Deutschland:
Sie dürfen das Werk bzw. den Inhalt zu jedem legalen Zweck nutzen, verändern und in unveränderter oder veränderter Form vervielfältigen, verbreiten und öffentlich zugänglich machen, sofern Sie den Namen des Autors/Rechteinhabers in der von ihm festgelegten Weise nennen.
Identifikatoren
Herausgeber
Erscheinungsjahr
Sprache
Produktionsjahr2025
ProduktionsortMunich

Inhaltliche Metadaten

Fachgebiet
Genre
Abstract
Self-assembly processes in biological and synthetic biomolecular systems are often governed by the spatial separation of biochemical processes. While previous work has focused on optimizing self-assembly through fine-tuned reaction parameters or using phase-separated liquid compartments with fast particle exchange, the role of slow intercompartmental exchange remains poorly understood. Here, we demonstrate that slow particle exchange between reaction domains can enhance self-assembly efficiency through a cooperative mechanism: delay-facilitated assembly. Using a minimal model of irreversible self-assembly in two compartments with distinct reaction and exchange dynamics, we identify scenarios where slow particle exchange maximizes yield and minimizes assembly time for given suboptimal reaction dynamics, even under conditions where isolated compartments would fail to facilitate any self-assembly. The mechanism relies on a separation of timescales between intracompartmental reactions and intercompartmental exchange and is robust across a wide range of geometries, including spatially extended domains with diffusive transport. We demonstrate that this effect enables geometric control of self-assembly processes through compartment volumes and exchange rates, eliminating the need for fine-tuning local reaction rates. These results offer a conceptual framework for leveraging spatial separation in synthetic self-assembly design and suggest that biological systems may use slow particle exchange to improve assembly efficiency.
Schlagwörter