One-pot processes have considerably enhanced diversity-oriented syntheses in the past decades and have become an enabling tool for providing myriads of substance libraries, in particular, in pharmaceutical high-throughput screening and lead finding. Over the past two decades, we have paved the way of multicomponent reactions (MCR) as a synthetic concept to access functional p-electron systems, such as chromophores, fluorophores, and electrophores, by scaffold and chromophore approaches. Transition metal catalyzed couplings are excellent entries to alkynones, which can be transformed by multi-component and domino processes to various classes of functional fluorescent chromophores in a one-pot fashion (chromophore concept). In the lecture the general concept is introduced and illustrated by the development of ethynyl quinoxalines and aroyl-S,N-ketene acetals, novel classes of polar solid-state and aggregation-induced emissive dyes. References L. Biesen, T. J. J. Müller, Chem. Eur. J. 2023, 29, e202302067. L. Brandner, T. J. J. Müller, Front. Chem. 2023, 11, 1124209. L. Biesen, T. J. J. Müller, Adv. Synth. Catal. 2021, 363, 980.