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One-pot multicomponent syntheses of functional chromophores

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Title
One-pot multicomponent syntheses of functional chromophores
Subtitle
Synthetic Efficiency Meets Functionality Design
Title of Series
Number of Parts
27
Author
License
CC Attribution 4.0 International:
You are free to use, adapt and copy, distribute and transmit the work or content in adapted or unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
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Publisher
Release Date2024
LanguageEnglish
Producer
Production Year2024
Production PlaceFrankfurt am Main

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Abstract
One-pot processes have considerably enhanced diversity-oriented syntheses in the past decades and have become an enabling tool for providing myriads of substance libraries, in particular, in pharmaceutical high-throughput screening and lead finding. Over the past two decades, we have paved the way of multicomponent reactions (MCR) as a synthetic concept to access functional p-electron systems, such as chromophores, fluorophores, and electrophores, by scaffold and chromophore approaches. Transition metal catalyzed couplings are excellent entries to alkynones, which can be transformed by multi-component and domino processes to various classes of functional fluorescent chromophores in a one-pot fashion (chromophore concept). In the lecture the general concept is introduced and illustrated by the development of ethynyl quinoxalines and aroyl-S,N-ketene acetals, novel classes of polar solid-state and aggregation-induced emissive dyes. References L. Biesen, T. J. J. Müller, Chem. Eur. J. 2023, 29, e202302067. L. Brandner, T. J. J. Müller, Front. Chem. 2023, 11, 1124209. L. Biesen, T. J. J. Müller, Adv. Synth. Catal. 2021, 363, 980.
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