We start by recalling the essential features of frames, both discrete and continuous, with some emphasis on the notion of frame duality. Then we turn to generalizations, namely upper and lower semi-frames, and their duality. Next we consider arbitrary measurable maps and examine the standard operators, analysis, synthesis and frame operators, and study their properties. Finally we analyze the recent notion of reproducing pairs. In view of their duality structure, we introduce two natural partial inner product spaces and formulate a number of open questions.