"Today, Python tools are used almost everywhere in astrophysics: From modelling the images of stars and galaxies seen in modern large telescopes, to statistical analyses of the data products, to inferring the history of our Universe. I will first give a general overview of the kind of Python packages used in the field and then go in to some specific examples of application that I am involved with. These include mapping the dark matter in the Universe and flying drones to calibrate radio telescopes."