Numerical modeling of the phenomena in multiphase flows is today a necessary stage when developing or improving materials, technology as well as processes. Model development is based on the understanding of the basic physical phenomena. For this purpose, it is essential to simultaneously carry out numerical and experimental studies on some basic configurations to understand all the underlying phenomena. Direct Numerical Simulations is a powerful tool to understand basic physics and to interpret some experimental observations. Particularly with the advance of supercomputers nowadays, the limits of DNS are constantly extending. This presentation gives some examples of research projects that simultaneously include DNS and experimental study on e.g., gas-fluidization, bubbly flows and wet granulation. Potential of DNS to describe the physical phenomena in gas-liquid-nanoparticle three phase flows is briefly discussed as well.