Lessons From Yeast - Autophagy: Intracellular Recycling System

Video in TIB AV-Portal: Lessons From Yeast - Autophagy: Intracellular Recycling System

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Title
Lessons From Yeast - Autophagy: Intracellular Recycling System
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CC Attribution - NonCommercial - NoDerivatives 4.0 International:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal and non-commercial purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
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Release Date
2018
Language
English

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Abstract
The cellular degradation process is highly regulated and plays critical roles in cell physiology. Autophagy is the major degradation process. Thirty years ago I found by light microscopy that yeast induces massive protein degradation within the vacuole under nutrient starvation. Electron microscopy revealed that membrane dynamics of this process are similar to macroautophagy in mammals. Then many autophagy-defective mutants were successfully obtained. 18 Atg proteins, required for the autophagosome formation, consist of six functional units, including a protein kinase complex, the PI3 kinase complex and two unique conjugation systems. The identification of ATG genes completely changed the landscape of autophagy research. Manipulation of these genes unveiled a truly broad range of physiological functions of autophagy. Autophagy plays important roles not only in nutrient recycling, but also intracellular clearance through the elimination of harmful proteins and damaged organelles. Now it is becoming clear that autophagy is relevant to many diseases and health problem.
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  176 ms - page object

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AV-Portal 3.20.1 (bea96f1033d39fbe77f82542458e108105398441)
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