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Linked Data based Multi-Omics Integration and Visualization for Cancer Decision Networks.

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Linked Data based Multi-Omics Integration and Visualization for Cancer Decision Networks.
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12
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CC Attribution 3.0 Germany:
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Visualization of Gene Expression (GE) is a challenging task since the number of genes and their associations are diffcult to predict in various set of biological studies. GE could be used to understand tissuegene- protein relationships. Currently, Heatmaps is the standard visualization technique to depict GE data. However, Heatmaps only covers the cluster of highly dense regions. It does not provide the Interaction, Functional Annotation and pooled understanding from higher to lower expression. In the present paper, we propose a graph-based technique - based on color encoding from higher to lower expression map, along with the functional annotation. This visualization technique is highly interactive (HeatMaps are mainly static maps). The visualization system here explains the association between overlapping genes with and without tissues types. Traditional visualization techniques (viz-Heatmaps) generally explain each of the association in distinct maps. For example, overlapping genes and their interactions, based on co-expression and expression cut off are three distinct Heatmaps. We demonstrate the usability using ortholog study of GE and visualize GE using GExpressionMap. We further compare and benchmark our approach with the existing visualization techniques. It also reduces the task to cluster the expressed gene networks further to understand the over/under expression. Further, it provides the interaction based on co-expression network which itself creates co-expression clusters. GExpressionMap provides a unique graphbased visualization for GE data with their functional annotation and associated interaction among the DEGs (Differentially Expressed Genes).
Linked dataDisintegrationVisualization (computer graphics)Decision theoryComputer networkInstance (computer science)Parameter (computer programming)INTEGRALDatabaseXMLLecture/Conference
MultiplicationLinked dataVisualization (computer graphics)DisintegrationDecision theoryComputer networkModule (mathematics)Population densityOpen setProjective planeDecision theoryXMLUML
MultiplicationLinked dataVisualization (computer graphics)DisintegrationComputer networkDecision theoryCommunications protocolTime evolutionAnalytic setEvoluteDecision support systemMereologyProgramming paradigmState of matterAreaPredicate (grammar)Error messageTheory of relativitySymmetry (physics)Machine visionMultiplication signPerformance appraisalField (computer science)Level (video gaming)Traffic reportingMedical imagingBitCommunications protocolComplete metric spaceChaos (cosmogony)Computer animation
DisintegrationQuicksortLogicFormal grammarOffice suiteAnalytic setAdditionDecision support systemProgramming paradigmDataflowSeries (mathematics)InferenceCondition numberSampling (statistics)AudiovisualisierungGraph (mathematics)Form (programming)Decision theoryFile formatEngineering drawing
Data managementMultiplicationMedical imagingComputer networkComputer-generated imageryProcess (computing)Single-precision floating-point formatDisintegrationPhysical systemElectronic signatureField (computer science)CondensationView (database)Message passingAnalytic setPersonal digital assistantQuicksortExecution unitOrder (biology)Mathematical analysisPointer (computer programming)Standard deviationConcordance (publishing)Single-precision floating-point formatMixed realityPoint (geometry)Modal logicMedical imagingPhysical systemFile formatGraph (mathematics)Web 2.0Different (Kate Ryan album)AreaTerm (mathematics)MultiplicationComputer animationProgram flowchart
Lie groupGraph (mathematics)Lemma (mathematics)DisintegrationMaxima and minimaExecution unitAxiomGraph (mathematics)Query languageCross-correlationSingle-precision floating-point formatComplex (psychology)Term (mathematics)InformationWebsiteSocial classDistributed computingObservational studyPhysical systemWave packetCAN bus1 (number)Identity managementStandard deviationCore dumpProgram flowchart
Lie groupDisintegrationMaxima and minimaEvent horizonSample (statistics)SubsetComputer networkDecision theoryDevice driverComputer networkSystem identificationBuildingRegulärer Ausdruck <Textverarbeitung>Rule of inferenceGraph (mathematics)ProteinDomain nameNatural numberProgram flowchartComputer animation
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Function (mathematics)Computer networkDecision theorySign (mathematics)Negative numberPairwise comparisonCross-correlationDisintegrationData modelParticle systemComplex (psychology)MathematicsEndliche ModelltheorieRule of inferenceGraph (mathematics)Random number generationComputer animation
Device driverFunction (mathematics)HypothesisoutputPerformance appraisalRule of inferenceDisintegrationQuery languageLocal ringDatabaseAngleMereologyVideo gamePhysical systemRule of inferenceDefault (computer science)NumberLevel (video gaming)Point (geometry)Endliche ModelltheorieProjective planeWeb crawler2 (number)Parameter (computer programming)Computer animation
FeedbackTranslation (relic)DisintegrationData modelProteinNumberExpressionPhysical systemEndliche ModelltheorieMultiplication signInteractive televisionMathematicianMathematical modelMereologyValidity (statistics)Computer animation
File formatFunctional (mathematics)Query languageSource codePlanningTransformation (genetics)DisintegrationGroup actionWaveAnalytic setPolygonQuery languageDrill commandsGraph (mathematics)AudiovisualisierungComputing platformParameter (computer programming)Type theoryAdditionMappingReading (process)ResultantHazard (2005 film)Endliche ModelltheorieData storage deviceComputer animation
Maxima and minimaThomas KuhnDisintegrationMenu (computing)Level (video gaming)Multiplication signPoint (geometry)TelecommunicationGroup actionDecision support systemSingle-precision floating-point formatEndliche ModelltheorieAudiovisualisierungComputer animation
Simultaneous localization and mappingMaxima and minimaGamma functionLemma (mathematics)Object (grammar)Event horizonInterior (topology)Level (video gaming)Scalable Coherent InterfaceComputer-generated imageryDisintegrationBitDenial-of-service attackAugmented realityDecision tree learningInternet forumUniform resource nameMIDIExecution unitChemical equationoutputEndliche ModelltheorieLevel (video gaming)Context awarenessDeconvolutionExpressionBitExecution unitInclusion mapTupleArtificial neural networkMathematicsType theoryConvolutionWave packetComputer animation
Single-precision floating-point formatMultiplicationComputing platformOntologyDisintegrationData analysisVisualization (computer graphics)Traffic reportingPredictionMoment (mathematics)OntologySubject indexing2 (number)Database normalizationTerm (mathematics)AudiovisualisierungInternet service providerComputer animation
Visualization (computer graphics)Decision theoryComputer networkoutputDisintegrationMultiplicationNormal (geometry)Arithmetic progressionInformationHypermediaConnected spaceType theorySelectivity (electronic)LaceProteinSource codeEndliche ModelltheorieLevel (video gaming)SoftwareFunction (mathematics)Decision theoryComputer animation
Visualization (computer graphics)Single-precision floating-point formatDisintegrationAudiovisualisierungMathematicsSystem identificationPlot (narrative)Principal component analysisPopulation densityDistribution (mathematics)Sample (statistics)Point (geometry)Observational studyControl flowNormal (geometry)AudiovisualisierungMultiplication signMedical imagingAdditionFluid staticsComputer animation
ProteinTable (information)DisintegrationStandard deviationTable (information)ExpressionConnected spaceGraph (mathematics)Computer animation
DisintegrationOntologySearch engine (computing)ProteinLevel (video gaming)Different (Kate Ryan album)Traffic reportingUniform resource locatorGenderPrisoner's dilemmaMedical imagingPhysical system
Medical imagingDisintegrationPointer (computer programming)Motif (narrative)WebsiteLattice (order)MetadataMedical imagingKonturfindungModule (mathematics)Trans-European NetworksPresentation of a groupComputer animation
DisintegrationSign (mathematics)Execution unitMultiplication signComputer animationLecture/ConferenceMeeting/Interview
DisintegrationCore dumpFunctional (mathematics)Multiplication signLevel (video gaming)XMLUMLComputer animation
Query languageCore dumpCrash (computing)Open setComputer animation
Level (video gaming)LogicStandard deviationLevel (video gaming)Order (biology)Student's t-testAssociative propertyCross-correlationIncidence algebraState of matterProjective planeTerm (mathematics)
DisintegrationComputer animationLecture/ConferenceMeeting/InterviewXMLUML
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