Apart from their foundational signicance, entropic uncertainty relations play a central role in proving the security of quantum cryptographic protocols. Of particular interest are thereby relations in terms of the smooth min-entropy for BB84 and six-state encodings. Previously, strong uncertainty relations were obtained which are valid in the limit of large block lengths. Here, we prove a new uncertainty relation in terms of the smooth min-entropy that is only marginally less strong, but has the crucial property that it can be applied to rather small block lengths. This paves the way for a practical implementation of many cryptographic protocols. As part of our proof we show tight uncertainty relations for a family of Renyi entropies that may be of independent interest.