Collaborative and interdisciplinary research, Open Source Estrogen combines biohacking and artistic intervention to demonstrate the entrenched ways in which estrogen is a biomolecule with institutional biopower. It is a form of biotechnical civil disobedience, seeking to subvert dominant biopolitical agents of hormonal management, knowledge production, and anthropogenic toxicity. Thus, the project initiates a cultural dialogue through the generation of DIY/DIWO (do-it-yourself/do-it-with-others) for the detection and extraction of estrogen, and contextualized as kitchen performance and queer body worship.