While we tend to think of Exascale as a hardware scaling problem, the required monumental exercise of software co-design between multiple teams tends to get overlooked. Software—the key crosscutting technology by which teams collaborate toward predictive science—is dramatically increasing in complexity due to disruptive architectural changes, multiphysics and multiscale modeling, the coupling of simulations and data analytics, and the demand for greater reproducibility and sustainability. In this session, Lois Curfman McInnes from Argonne National Laboratory and Rich Brueckner from insideHPC will moderate a panel discussion with thought leaders focused on software challenges for Exascale and beyond – mixing “big picture” and technical discussions. McInnes will bring her unique perspective on emerging Exascale software ecosystems to the table, while Brueckner will illustrate the benefits of Exascale to world-wide audiences.