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Why do we get Alzheimer's disease?

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Title Why do we get Alzheimer's disease?
Author Tony Wyss-Coray
Publisher SLAC National Accelerator Laboratory (SLAC)
Release Date 2006
Language English

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Subject Area Physics
Abstract Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

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