Putting the Squeeze on Biology: Biomolecules Under Pressure


Formale Metadaten

Titel Putting the Squeeze on Biology: Biomolecules Under Pressure
Autor Sol Gruner
Herausgeber Fermi National Accelerator Laboratory (Fermilab)
Erscheinungsjahr 2007
Sprache Englisch

Inhaltliche Metadaten

Fachgebiet Physik
Abstract Modest pressures encountered in the biosphere (i.e., below a few kbar) have extraordinary effects on biomembranes and proteins. These include pressure denaturation of proteins, dramatic changes in protein-protein association, substrate binding, membrane ion transport, DNA transcription, virus infectivity, and enzyme kinetics. Yet all of the biomaterials involved are highly incompressible. The challenge to the physicist is to understand the structural coupling between these effects and pressure to elucidate the relevant mechanisms. X-ray diffraction studies of membranes and proteins under pressure will be described. It is seen that it is not so much the magnitude of the changes, but rather the differential compressibilities of different parts of the structure that are responsible for effects.

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