In this work, a framework for large-scale structural applications of 3D printed con-crete is presented, which serves as an important step to develop a regulatory basis for ap-proval in the Netherlands. The steps in this framework, consisting of a design phase, testing phase and manufacturing phase, towards a final output were presented and discussed theo-retically. The framework was then applied to the case of a 29 m 3D printed bridge, funded by Rijkswaterstaat Major Projects and Maintenance, constructed in the Netherlands. The full application of the framework illustrates that despite the absence of standards, it is possible to safely apply 3D printed structures in practice. With the gradual increase of testing data ex-pected to become available over the coming years, the extent of the application of the framework can be reduced step-by-step.