This video shows the synthesis and applications of new metal compounds for biomedical applications. We use elements all across the periodic table according to the required properties, for example iron, ruthenium, rhenium or gold. Metal ions play a vital role in biology. They are cofactors in many enzymes, and they even form part of the active center in as much as one third of all enzymes in the human body. Furthermore, metal compounds have an important role for the human well-being. A few metal complexes even serve as drugs, for example against cancer and bacterial infections. However, this field of metal-based drugs is notably less developed compared to purely organic drugs. Our group explores the synthesis and applications of new metal compounds for biomedical applications. We use elements all across the periodic table according to the required properties, for example iron, ruthenium, rhenium or gold. A particular focus of our work is to exploit the unique properties provided by the metal atoms, such as redox activity or optical properties; and to develop highly cell and tissue-specific, targeted metal bioconjugates. The group runs a full research program including not only synthesis but also physical characterization and investigation of their biological properties. This video gives an overview of the various aspects of our work and an outlook to international cooperations in the field of medicinal inorganic chemistry. |