Homoeriodictyol (HED) is a flavan type natural product active as bitter blocker. It was used as a lead compound to identify further natural products with a similar activity in silico and by sensory evaluation. In addition to conventional chemical synthesis, there is a demand for biotechnological production means of food additives. Therefore, enzyme cascades able to convert available natural precursors to high value products have been identified. Enzymes are rationally re-designed in silico for better performance, and then combined in vitro and in vivo for the one pot production of the target compound. Research in the Wessjohann group combines several disciplines like natural product discovery, analysis and chemical synthesis, computational chemistry, molecular biology and protein biochemistry to succeed.