HPC systems have been traditionally operated as monolithic installations on bare-metal hardware primarily used by users with computational background to submit classic batch jobs. However the commoditization of compute resources and the introduction of new scientific fields such as life sciences to high performance computing has caused a shift in this paradigm. Today, an increasing number of biological software is made accessible through web portals. This improved ease of use has led towards a democratization of access to computational resources Users of those fields don’t have the same computational knowledge as traditional HPC users from physics or chemistry and additionally require different kinds of workloads and applications that don’t fit traditional non-interactive batch scheduling resource management systems. Additionally, cloud computing is becoming more and more relevant and various efforts to lift HPC into the Cloud were started.