UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: Announcements 0:00:21- Announcements 0:01:24- Midterm 1 Results 0:03:24- Office Hours 0:04:28- Getting Strong Letters of Recommendation 0:15:10- Getting Strong Letters of Recommendation from Prof. Weiss Lecture 0:18:00 DNA Chemistry and Cancer 0:21:00 RNA: Soldier, Sailor, Tinker, Spy 0:22:40 Differences Between RNA and DNA 0:23:25 RNA Hydrolysis 0:27:27 Rnase Mechanism of Action 0:30:38 How to Shut Down a Very Effective Enzyme 0:33:25 The 5-Methyl Group of Thymine Provides a Chemical Code for DNA 0:36:35 RNA Bases can Be Modified 0:38:14 RNA Adopts Globular Structures 0:40:14 Systemizing Structure in RNA 0:46:20 RNA Polymerase 0:50:40 DNA Primase 0:52:27 Transcription in Action 1:15:32 The Yeast Two-Hybrid System Allows in Cell Testing for Binding 1:17:53 Comparing Bacterial and Eukaryotic mRNA Factors