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05:03
10Allen, Karen N. et al.
Karen N. Allen talks about what she considers to be the major challenges of a successful investigation of protein structure–function relationships. She emphasizes the intricate connection between the motion of enzymes and their catalysis. This, in turn, necessitates the employment of techniques that capture the motion of the protein and are able to correlate the gathered data with the chemistry. Karen N. Allen is a professor at the Department of Chemistry of the Boston University in Massachusetts. Her research is focused on various aspects of protein structure and function.
2011Beilstein-Institut zur Förderung der Chemischen Wissenschaften
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06:16
3Leyh, Thomas S. et al.
There is a tremendous amount of information that is not yet fully understood about how proteins function. An enzymatic catalysis presents itself as an immensely complex mechanism: solvation and desolvation takes place, entropy and enthalpy are redistributed, intramolecular interactions in the protein matrix and intermolecular interactions occur, and the binding energy continuously changes when the catalytic cycle takes its course. The impact of the Commision for Standards for Reporting Enzymology Data (STRENDA) on the biological community is also discussed. Thomas S. Leyh is a professor of Biochemistry at the Albert Einstein College of Medicine in New York. He is a mechanistic enzymologist with a research focus on sulfur biochemistry, GTPase function, and the conformational coupling of energetics. He is also a founding member of the STRENDA Commission.
2011Beilstein-Institut zur Förderung der Chemischen Wissenschaften
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08:03
1Armstrong, Richard et al.
Richard N. Armstrong talks about the Enzyme Function Initiative EFI and its role in developing a robust strategy to assist in the discovery of enzymatic and metabolic functions of hitherto uncharacterized enzymes. The achievement of EFI’s goals are only feasible due to the multidisciplinary cooperation of the participating scientists. EFI is strongly dependant on the availability of standardized functional data. Richard Armstrong also stresses that the reporting and deposition of high quality data has to be enforced by the community, that is, the funding agencies, the scientific journals, and advocates such as the Commission for Standards for Reporting Ennzymology Data (STRENDA). Richard N. Armstrong is professor of Biochemistry and Chemistry at the Vanderbuilt University in Nashville, Tennessee. His research interests encompass the elucidation of the mechanisms of action of enzymes involved in the metabolism of foreign compounds. More specifically, his research efforts are focused on the cooperation of detoxication enzymes in the metabolism of foreign molecules as well as the enzymology of antibiotic resistance in microorganisms.
2012Beilstein-Institut zur Förderung der Chemischen Wissenschaften
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06:31
12Ebenhoeh, Oliver et al.
Oliver Ebenhoeh talks about biological systems and their many layers of organization, each of which contributes to the overall complexity of a system. He presents his research interest in metabolic modelling that aims for the complete reconstitution of a particular metabolic pathway in the computer, thus being able to simulate the pathway. Oliver Ebenhoeh also voices his opinion about two critical problems in modern-day biology: the reliability and reproducability of experimental data. Oliver Ebenhoeh is an associate professor in systems biology at the Institute for Complex Systems and Mathematical Biology, University of Aberdeen, UK. The aim of Oliver Ebenhoeh’s research is the combination of physics and biology to understand the design principles of cellular interaction networks by means of theoretical approaches.
2012Beilstein-Institut zur Förderung der Chemischen Wissenschaften
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05:12
13Cornish-Bowden, Athel et al.
Athel Cornish-Bowden talks about the characteristics of metabolic regulation and metabolic control, and differentiates between the two of them. He also talks about the relationship between metabolic control analysis and systems biology. Athel Cornish-Bowden is a Directeur de Recherche (Émérite) at the Centre National de la Recherche Scientifique (CNRS) in Marseilles, France. Although he started his career in a department of organic chemistry, virtually all of his current research is carried out in the realm of biochemistry. His research is focused on enzymes, in particular on pepsin, mammalian hexokinase, and enzymes involved in electron transport in bacteria. He has also authored several books related to enzyme kinetics.
2012Beilstein-Institut zur Förderung der Chemischen Wissenschaften