The microscope is an essential tool in many areas of scientific research. In this video, ULRIKE FUCHS explains how the latest developments in laser technology can significantly improve microscopy. * Focusing on fluorescence microscopy, Fuchs demonstrates the advantages of using a laser with a “top hat” shaped beam distribution in place of the standard Gaussian beam distribution. * Delivering striking improvements in areas including photo bleaching and high throughput stitching, the research also has important implications for common and stimulated emission depletion (STED) microscopy. This LT Publication is divided into the following chapters: 0:00 Question 1:35 Method 3:42 Findings 6:39 Relevance 7:59 Outlook