We're sorry but this page doesn't work properly without JavaScript enabled. Please enable it to continue.
Feedback

Chemistry and biology: alkaloid biosynthesis in plants

00:00

Formal Metadata

Title
Chemistry and biology: alkaloid biosynthesis in plants
Subtitle
Elucidating and Engineering Natural Product Pathways in Plants
Title of Series
Number of Parts
Author
License
CC Attribution - NoDerivatives 4.0 International:
You are free to use, copy, distribute and transmit the work or content in unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor.
Identifiers
Publisher
Release Date
Language

Content Metadata

Subject Area
Genre
Abstract
Many enzymatic transformations are utilized in the biosynthesis of the monoterpene indole alkaloids, a group of structurally diverse natural products. Here we describe the discovery, functional characterization and mechanistic study of several enzymes involved in the biosynthesis of the monoterpene indole alkaloids in Catharanthus roseus. Also discussed are the implications of this work in the metabolic engineering of natural products.
Keywords
AlkaloidBiosynthesisChemistryMarshFunctional groupOrganic chemistryHope, ArkansasAzo couplingFunctional groupBleiglanzComputer animationLecture/ConferenceMeeting/Interview
Pharmaceutical drugVinblastineTaxolBulk modulusOrganic chemistryNaturstoffSecondary metaboliteChemical plantThermalquellePharmaceutical drugOrigin of replicationMoleculeOpiumChemotherapyAlkaloidDigoxinSample (material)Chemical compoundAnomalie <Medizin>MetaboliteGesundheitsstörungForkhead-GenWursthülleAgeingTotalsyntheseKlinische ChemieMorphineLecture/ConferenceComputer animation
VinblastinePharmaceutical drugChemical plantPsychopharmakonYield (engineering)Chemical plantWursthüllePharmaceutical drugTotalsyntheseChemical compoundNaturstoffChemotherapyVinblastineRiver sourceBiochemistryEnzymeMetabolic pathwayPrimer (film)Yield (engineering)Hope, ArkansasSynthetic oilLecture/ConferenceMeeting/InterviewComputer animation
VinblastineMetabolic pathwayEnzymeBiosynthesisGenregulationWine tasting descriptorsMoleculeSea levelChemical compoundBiochemistryHost (biology)EnzymeNaturstoffMetabolic pathwayProcess (computing)Chemical compoundAzo couplingBiochemistrySea levelVinblastineMoleculeMultiprotein complexTransportChemical plantComputer animation
CamptothecinYohimbineVinblastineChemical compoundAmineAcidIndoleAlkaloidTryptaminIridoidglykosideChemical compoundMaterials scienceChemistryAnomalie <Medizin>NaturstoffChemical structureChemical plantOrganic chemistryChemische SyntheseMedical historySetzen <Verfahrenstechnik>Azo couplingExtractPolysulfoneAlkaliBiosynthesisVinblastineMolecular geometryComputer animation
ChemistryExtractAlkaloidExtractMetabolismChemical plantHydrophobic effectChemistryErdrutschMetabolic pathwayBiochemistryTiermodellThermoformingSynthetic oilChemical reactionNaturstoffAlkaloidBiosynthesisVinblastineChemische SyntheseTool steelMolecular geometryComputer animation
AlkaloidBiomolecular structureEnzymeGeraniolWalkingSetzen <Verfahrenstechnik>ChemistrySynthetic oilMetabolic pathwayMolecular geometry
MorphineVinblastineTaxolChemical plantMetabolismVinblastineChemical compoundAzo couplingChemische SyntheseActivity (UML)Chemical plantNaturstoffMetabolic pathwayBiosynthesisErdrutschMorphineNecking (engineering)EnzymeTaxolLecture/ConferenceMeeting/InterviewComputer animation
Biomolecular structureGenomeChemical plantGeneEnzymeChemical plantBiomolecular structureGenomeMetabolismBiosynthesisGene clusterGeneWursthülleChromosomeNecking (engineering)Sense DistrictNaturstoffAzo couplingPainMetabolic pathwaySynthetic oilErdrutschBiochemistry
Azo couplingGezeitenküsteGenomeGenePolyketideBiosynthesisEnzymeMetabolismChemistryNaturstoffBiochemistryChemical plantProcess (computing)Computer animationLecture/Conference
GenomeBiomolecular structureGeneChemical plantGenomeProcess (computing)GeneMetabolic pathwayEnzymeMetabolismChromosomeWursthülleLeadChemische SyntheseBiochemistrySynthetic oilWalkingLecture/ConferenceMeeting/Interview
BiosynthesisAcetoxy groupTranscription (genetics)MethoxygruppeMethylgruppeCognacLocus (genetics)BiosynthesisWalkingLeadVinblastineData conversionChemistryMetabolic pathwayEnzymeMoleculeMethylgruppeOrganic chemistryAmino acidPharmacyStuffingHydroxylChemische SyntheseBiomolecular structureGenePeptide sequenceGenomeCatheterElektronentransferTranskriptomanalyseLecture/ConferenceComputer animation
Mas (Provençal farmhouse)Locus (genetics)VealAltbierDarmstadtiumTranscription (genetics)DNS-SyntheseMessenger RNATranskriptomanalyseBiomolecular structurePharmaceutical drugGeneChemical plantTranscription (genetics)Gene expressionLecture/ConferenceTable
Library (computing)Locus (genetics)Table wineAlumGesundheitsstörungGenregulationTranscription (genetics)Gene expressionThermoformingGeneSeedlingNaturstoffLocus (genetics)CatheterStress (mechanics)AlkaloidComputer animationTableLecture/Conference
Locus (genetics)FlourEnzymeRedoxGeneSeedlingSea levelAluminateGeneGene expressionSetzen <Verfahrenstechnik>MetalElektronentransferTidal raceEnzymeOxideCytochrom P-450BiosynthesisAmineFeed (film)Transcription (genetics)MachinabilityMethylgruppeFunctional groupChemische SyntheseComputer animationTableLecture/Conference
GeneEnzymeRedoxFiltermittelTranscription (genetics)Methyltransferase <S>GeneBiosynthesisGene expressionChromosomeTransformation <Genetik>WursthülleElektronentransferSet (abstract data type)MethylgruppeLecture/ConferenceMeeting/InterviewComputer animation
International Nonproprietary NameLocus (genetics)GeneSea levelGene clusterSetzen <Verfahrenstechnik>GeneAzo couplingErdrutschTranscription (genetics)ProteinfamilieSetzen <Verfahrenstechnik>Spawn (biology)Program flowchart
EnzymeMethylgruppeSubstrat <Chemie>Gene clusterGene expressionCalcium hydroxideS-Adenosyl methionineMethyltransferase <S>Breed standardGenomeBreed standardBiochemistryGene expressionShuttle-VektorFunctional groupSubstrat <Chemie>ElektronentransferTidal raceChemical reactionMethylgruppeTiermodellS-Adenosyl methionineTrace elementEnzymeCofactor (biochemistry)PainNecking (engineering)SandAcidData conversionMetalLecture/ConferenceMeeting/InterviewComputer animation
Breed standardGeneGene silencingSeedlingMissernteMetaboliteRNAPhotochemistryData conversionEnzymkinetikPharmacokineticsChemical reactionCoke (fuel)MetabolismChemical plantTiermodellSetzen <Verfahrenstechnik>Substrat <Chemie>Activity (UML)EnzymeWursthülleDiagramLecture/ConferenceComputer animation
GeneGene silencingSeedlingMissernteMetaboliteRNAPhotochemistryFunctional groupMetabolic pathwayEnzymeWursthülleFeed (film)Data conversionSubstrat <Chemie>Gene expressionNaturstoffChemical plantSilencer (DNA)GeneRNA interferenceShuttle-VektorEconomic sectorMeeting/InterviewComputer animation
GeneGene silencingSeedlingMissernteMetaboliteRNAPhotochemistryPlasmidSolutionStem cellProcess (computing)Chemical plantDNS-SyntheseShuttle-VektorReaction mechanismElektronentransferMetalComputer animation
GeneGene silencingSeedlingMissernteMetaboliteRNAPhotochemistryGeneStop codonMetabolic pathwaySea levelPlasmidMessenger RNAController (control theory)Silencer (DNA)EthanolTrace elementMeatTidal raceMetalChemische SyntheseElektronentransferHydrophobic effectComputer animation
Grus (geology)PhotochemistryAcetoxy groupGeneMetabolismAlkaloidEnzymeBiomolecular structureTocopherolMethyltransferase <S>PyrophosphateTitanium carbideSubstrat <Chemie>Sea levelBreed standardSeedlingChemical compoundContainment buildingEnzymeElektronentransferMethylgruppeTrauma (medicine)GeneMetabolic pathwaySetzen <Verfahrenstechnik>Methyltransferase <S>Chemical plantBiomolecular structureWalkingSurvival skillsChemical reactionTocopherolOcean currentMultiprotein complexWursthülleAromaticityMetabolismMetalGallussäureGenotypeActivity (UML)Tidal raceHuman subject researchMoleculeBlood vesselChemische SyntheseComputer animation
IndoleAlkaloidTerpeneMeatIridoidglykosideBiosynthesisChemical reactionBiosynthesisGenotypeActivity (UML)Methyltransferase <S>Biomolecular structureResidue (chemistry)PainWalkingChemical compoundChemistryTranscription (genetics)KatalaseEnzymeTerpeneIngredientSetzen <Verfahrenstechnik>AlkaloidAgricultureFeed (film)ThermoformingElektronentransferLecture/ConferenceComputer animation
GeneRedoxEnzymeChemical compoundBiochemistrySetzen <Verfahrenstechnik>PheromoneGeneTranscription (genetics)SteroidAnomalie <Medizin>International Nonproprietary NameTransformation <Genetik>ElektronentransferEnzymeMetabolic pathwayLecture/Conference
GeneRedoxEnzymeFiltermittelGene expressionCocaLocus (genetics)Transcription (genetics)BiochemistryGeneMetabolic pathwaySetzen <Verfahrenstechnik>EnzymeTranscription (genetics)Gene expressionAlkaloidElektronentransferComputer animationLecture/Conference
Lamination (geology)HydroxylierungCytochromeLocus (genetics)Gene expressionSea levelSeedlingTranscription (genetics)Chemical plantFunctional groupWursthülleAdenylate cyclaseGeneBiosynthesisSubstrat <Chemie>EnzymeHydroxylWalkingBiochemistryCyclische VerbindungenChemische SyntheseAgeingLecture/ConferenceMolecular geometry
EnzymePopliteales PterygiumsyndromChemistryMetabolismMetabolic pathwayPyrophosphateTerpeneSynthaseAlcoholSubstrat <Chemie>BiosynthesisAdenylate cyclaseChemical compoundPrecursor (chemistry)Cytochrom P-450DiolAldehydeHope, ArkansasEnzymeElectronic cigaretteBiochemistrySea levelPhosphateHydroxylPhase (waves)Potenz <Homöopathie>Reaction mechanismOxideChemische SyntheseDehydrogenaseLecture/ConferenceComputer animation
Adenylate cyclaseTerpeneCyclische VerbindungenChemical plantMoleculeSubstrat <Chemie>AldehydePhosphateCarbokationAnomalie <Medizin>MixtureRearrangement reactionChemical structureCofactor (biochemistry)Wine tasting descriptorsStorage tankActivity (UML)ProteinISO-Komplex-HeilweiseIslandChemical reactionKatalaseExtractEnzymeLecture/ConferenceComputer animation
Locus (genetics)AlcoholMultiple chemical sensitivityHomologisierungVakuumverpackungThylakoidNADPHEnzymeHydroxylierungDehydrogenationMast cellAdenosineCytochromeDoxorubicinSodium dodecyl sulfateHydroxylHydrodesulfurierungBeta sheetPhosphateZincEnzymeBeta sheetPlasmidWine tasting descriptorsGeneCofactor (biochemistry)Transcription (genetics)Gene expressionRefrigeratorHydroxylAngiotensin-converting enzymeReaction mechanismComputer animation
EnzymeTerpeneAdenylate cyclaseSpontaneous combustionSubstrat <Chemie>AldehydeNADPHDünnschichtchromatographieAnisaldehydDestraktionTuberculosisSpectroscopyBreed standardBarrel (unit)Shuttle-VektorCognacChemical compoundGeneFunctional groupPhantom <Medizin>AageLeadBeta sheetTuberculosisEnzymeSetzen <Verfahrenstechnik>Synthetic oilChemical reactionSea levelBreed standardHomologisierungAldehydeAlkaloidPrecursor (chemistry)Chemical structureCloningEnzymkinetikActivity (UML)SpeciesChemical compoundDoppelbindungChemical plantMetaboliteChromatographyCyclische VerbindungenSubstrat <Chemie>Mass spectrometryDerivative (chemistry)Silencer (DNA)ChemistryFunctional groupEnolHydrideDiet foodWine tasting descriptorsElektronentransferISO-Komplex-HeilweiseCatheterRefrigeratorHydroformylationBase (chemistry)CollisionLone pairZunderbeständigkeitOctane ratingAlcoholCoalCofactor (biochemistry)WerkstoffnummerChemical propertyMeatLecture/Conference
FluorescenceRNACytosolFunctional groupStratotypEnzymeCytosolChemical plantChemical structureFunctional groupCell (biology)MetabolismOrganic chemistrySetzen <Verfahrenstechnik>InfiltrationsanästhesieMetabolic pathwayAdenylate cyclaseComputer animationLecture/Conference
RNAFluorescenceIridoidglykosideCytosolFunctional groupReaction mechanismStereochemistryNADPHChemical bondPhysical chemistrySpontaneous combustionAdenylate cyclaseReduction potentialSet (abstract data type)Active siteEnzymeCarbon (fiber)Setzen <Verfahrenstechnik>ElectronWursthülleReaction mechanismMeat analogueSynthetic oilThermoformingAtom probeEtherSpeciesScaffold <Biologie>Molecular modellingChemistryHydroxylCell (biology)IonenbindungSubstrat <Chemie>WhitewaterMatchCobaltoxideReducing agentQuartzOptical coherence tomographyISO-Komplex-HeilweiseHydrideChemical reactionLightningAldehydeAnomalie <Medizin>Cofactor (biochemistry)ErdrutschHybridisierung <Chemie>Chemical structureTiermodellKetoneFunctional groupEnolBeta sheetTautomerAdenylate cyclaseEnoneCyclische VerbindungenMethoxygruppeMolecularityComputer animation
IridoidglykosideElectronChemical reactionChemische SyntheseActivity (UML)Reduction potentialZunderbeständigkeitEnzymeReaction mechanismChemical reactionHydroformylationReducing agentRock (geology)Activity (UML)RedoxZunderbeständigkeitEnzymeGeraniolBy-productAldehydeBeta sheetComputer animation
Reaction mechanismReduction potentialBreed standardTerpeneSetzen <Verfahrenstechnik>EnzymeNADPHBiosynthesisSubstrat <Chemie>AldehydeChemistrySubstrat <Chemie>Setzen <Verfahrenstechnik>EnzymeChemical reactionTerpeneAdenylate cyclaseBeta sheetAldehydeAzo couplingReducing agentChemistryCobaltoxideSilencer (DNA)Active siteMolecular geometryComputer animation
Reduction potentialBiosynthesisAldehydeChemistryEnzymeSemioticsLysergic acid diethylamideChemische VerschiebungChemical reactionWursthülleDyeingGesundheitsstörungSetzen <Verfahrenstechnik>ISO-Komplex-HeilweiseChemical compoundActivity (UML)Substrat <Chemie>Chemical structureReducing agentZunderbeständigkeitCobaltoxideEnzymeDoppelbindungChemische SyntheseSpeciesIonenbindungOptische AktivitätChemical plantCyclische VerbindungenBeta sheetDiolAldehydeActivation energyBiosynthesisComputer animation
VinblastineTransformation <Genetik>MarshChemistryBiochemistryActive siteBioavailabilityEnzymeHalogenationBiochemistryChemical structureAction potentialChemische SyntheseActivity (UML)Metabolic pathwayActivation energyNaturstoffEnzymeMetabolismVinblastineMeat analogueAzo couplingBiosynthesisLecture/Conference
BiochemistryBioavailabilityActive siteChemistryHalogenationEnzymeNaturstoffEnzymeSetzen <Verfahrenstechnik>HalogenTool steelBioavailabilityTryptophanPrecursor (chemistry)MetabolismChlorineBromineIndoleAnomalie <Medizin>Posttranslational modificationChemical structureSynthetic oilBiochemistryMetabolic pathwayAgeingElectronic cigaretteMolecular geometry
BiochemistryBioavailabilityActive siteChemistryEnzymeHalogenationMixtureTryptophanGrade retentionSynthetic oilMetabolismGeneGene expressionMetabolic pathwayMixtureSetzen <Verfahrenstechnik>EnzymeTryptophanTryptaminIndolalkaloideBiosynthesisMetabolic pathwayOrganic chemistryPotenz <Homöopathie>HalogenAlkaloidAntigenData conversionTerpeneChemical compoundGenotypeStereoselectivityActive sitePrecursor (chemistry)CarboxylateResidue (chemistry)Functional groupSystemic therapyAgeingSubstrat <Chemie>Computer animation
Lecture/ConferenceComputer animation
Transcript: Englisch(auto-generated)