The human microbiome is a diverse community of bacteria that lives inside us. Their contribution towards our personal well-being or sickness is controversially discussed within the scientific world and, likewise, in our society. First attempts to rationally (reverse-)engineer the human microbiome are hyped in medicine and within the DIY biohacking scene. The implications of these endeavours potentially concern several aspects of our life: eating habits, fitness state, susceptibility for infections, aging, and cancer. But what about ethical aspects of hacking the human microbiome? How can biosafety be maintained? Are there any data security issues? I will seriously discuss the state-of-the-art and future directions of the research to show whether actual hacking of the human microbiome is rather science or fiction.