UCI Chem 128 Introduction to Chemical Biology (Winter 2013) Instructor: Gregory Weiss, Ph.D. Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways. Index of Topics: 0:03:13 Cell Signaling 0:07:19 The 7 Signaling Pathways 0:09:41 Control Over Cell Differentiation Through Cytokines 0:12:04 Erythroproietin Signals Through the Jak-STAT Pathway 0:16:03 Chemical Control Over Cell Signaling Through Dimerization 0:22:25 Modification of Proteins for Better Properties 0:25:57 Growth Factor Signaling Through Cell surface Kinases 0:33:19 Sequential Phosphorylation 0:34:22 MAP Kinaase signaling 0:36:00 Peptide Binding Domains 0:38:32 Small Molecules in Cell Signaling 0:42:48 G Protein-Coupled Receptors 0:58:15 Vision Through Cis-Trans Olefin Isomerization 1:01:35 Ion Channel Signaling 1:03:31 Trimeric Death Receptors 1:04:38 Signaling by Diffusible Gas MOlecules 1:06:58 NO Causes Relaxation of Smooth Muscle in Blood Vessles 1:08:38 Chemical Biology: Review