The following video is an original recording of the opening lecture to the OSTI pilot initiative, hosted by the Doctoral Training Centres in Systems Biology, Life Sciences and the Industrial Doctorate at the University of Oxford. Entitled "Reproducibility and Open Science", the seminar identifies some of the current issues facing scientific research and introduces the theme of open science as a possible solution. Prospective OSTI course leaders may be interested in the end of the lecture, which provides an explanation of the Rotation Based Learning (RBL) implementation.