Open research is increasingly a strategic priority for research institutions, frequently driven by a range of institutional, national, and regional policies, contributing to significant regional differences. This presentation will share insights from a recent leadership roundtable discussion hosted by the transnational OCLC Research Library Partnership, with perspectives from approximately 35 research libraries in the US, Canada, UK, and Australia. With a focus on the role of the library, this presentation will examine how institutions are supporting open research, addressing strategic priorities, services, collaborations, and even the formation of new campus units. It will explore regional differences and also consider how external factors like national security, cybersecurity, AI, and growing scrutiny of international collaborations may be impacting open research goals and activities.