Synthesis of Oligoarabinofuranosides
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| Number of Parts | 22 | |
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| License | CC Attribution 3.0 Unported: You are free to use, adapt and copy, distribute and transmit the work or content in adapted or unchanged form for any legal purpose as long as the work is attributed to the author in the manner specified by the author or licensor. | |
| Identifiers | 10.5446/14090 (DOI) | |
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BiosynthesisChemistryPectinPsychopharmakonGalactaneMoleculeMan pageElectron donorAmalgam (chemistry)CollectingMonosaccharidePectinZunderbeständigkeitElektronenakzeptorSide chainElectron donorDisaccharideMetastasisSynthetic oilGolgi apparatusCancerIndiumLecture/Conference
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DisaccharideElectron donorChemistryBlock (periodic table)ElektronenakzeptorMoleculeDisaccharideActive siteArabinoseElectron donorISO-Komplex-HeilweiseElektronenakzeptorWalkingComputer animation
Transcript: English(auto-generated)
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Modified citrus pectins has been found to inhibit galactin 3, which plays a role in many stages of cancer progression and metastasis. However, our understanding of the in-view effects of these pectins are very limited at present. It is therefore interesting to prepare parts of pectin in a scale that makes it possible
00:24
to do biological tests. Here is a schematic representation of pectin, which consists of a backbone of rhamno-galactrin with side chains of 1.4-linked galactins and 1.5-linked arabinins, along with arabinins
00:43
branched in the 2 and 3 position. The synthetic strategy involves preparing a disaccharide donor from a monosaccharide acceptor and monosaccharide donor, which are both reachable from L-arabinose in 3-5 steps.
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So far, this disaccharide donor has been prepared from the combined acceptor and donor. Afterwards, the armed-disarmed effects of L-arabinofranocytes will be examined to prepare different kinds of disaccharides, for instance this one.